Alveolar concentration of nitric oxide predicts pulmonary function deterioration in scleroderma

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Alveolar concentration of nitric oxide predicts pulmonary function deterioration in scleroderma.

BACKGROUND Respiratory failure is a life-threatening and unpredictable complication of systemic sclerosis (SSc). A study was undertaken to assess the value of alveolar nitric oxide (NO) in predicting the risk of lung function deterioration leading to respiratory failure or death in patients with SSc. METHODS 105 patients with SSc were enrolled in this prospective cohort and were followed long...

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Severity of scleroderma lung disease is related to alveolar concentration of nitric oxide.

The alveolar concentration of exhaled nitric oxide (CA,(NO)) is increased in patients with systemic sclerosis (SSc), but whether this increase is related to the severity of interstitial lung disease (ILD) in SSc has not yet been investigated. In total, 58 SSc patients prospectively underwent pulmonary function tests (PFTs), echocardiogram and fibrosis scoring on pulmonary computed tomography (C...

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Peripheral airway/alveolar nitric oxide concentration in asthma.

We read with great interest the paper by Gelb and colleagues who suggest that peripheral airway/alveolar nitric oxide (NO) concentration after correction for axial NO back-diffusion (CalvNOcorrected) is normal during asthma exacerbation (with a hypothesis of an incidence of >30% of its increase). If one admits that an exacerbation constitutes the ultimate expression of loss of asthma control, t...

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Peripheral airway / alveolar nitric oxide concentration in asthma

REFERENCES 1. Moore RP, Berlowitz DJ, Denehy L, et al. A randomised trial of domiciliary, ambulatory oxygen in patients with COPD and dyspnoea but without resting hypoxaemia. Thorax 2011;66:32e7. 2. Nonoyama ML, Brooks D, Guyatt GH, et al. Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia. Am J Respir Crit Care ...

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ژورنال

عنوان ژورنال: Thorax

سال: 2011

ISSN: 0040-6376,1468-3296

DOI: 10.1136/thoraxjnl-2011-200499